Leonard and Sheldon are brilliant physicists, the kind of "beautiful minds" that understand how the universe works. But none of that genius helps them interact with people - especially women. All this changes when a free-spirited beauty named Penny moves in next door. Sheldon, Leonard's roommate, is quite content spending his nights playing Klingon Boggle with their socially dysfunctional friends, fellow Caltech scientists Howard Wolowitz and Rajesh Koothrappali. Leonard, however, sees in Penny a whole new universe of possibilities ... including love.