It’s 1958 and the hard-working midwives of Nonnatus House continue to serve the crowded tenements and slums of Poplar. As they struggle with the challenges of poverty, domestic abuse and the spectre of TB, the midwives also face crises of their own. A chance encounter reunites Jenny with Jimmy; Chummy and P.C. Noakes face a dilemma over their imminent future; a tragic birth puts Cynthia in the spotlight and Trixie enjoys an all-too-tantalising taste of celebrity lifestyle.

Back at Nonnatus House, Sister Julienne struggles to keep the beleaguered convent on an even keel as dementia-stricken Sister Monica Joan finds comfort in the friendship of new orderly, Jane; Sister Bernadette experiences a spiritual crisis and Sister Evangelina puts her foot down regarding pain relief.