In May 2009, Human Nature began a year-long engagement in Las Vegas at the Imperial Palace Hotel and Casino, performing 6 nights a week. They were the first Australian band ever to have a residency on the strip.

At the time, the group made a brief return to Australia in December 2009 to perform a "homecoming" show with Smokey Robinson at the Wyndham Estate winery in the NSW Hunter Valley wine region.

On May 11, 2010, Human Nature announced that the Imperial Palace had signed them for a further two years, and had also given the group the honour of renaming the Imperial Palace Showroom after them. The guys are now performing 6 nights a week in the "Human Nature Theatre".

As a special bonus, the mayor of Las Vegas - Oscar Goodman - decreed that May 11, 2010 would be known as "Human Nature Day".